KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
18.48
Human Site:
S1441
Identified Species:
29.05
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1441
K
S
L
H
D
K
K
S
Q
D
F
G
N
L
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1449
K
S
L
H
D
K
K
S
Q
D
F
G
N
L
F
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1435
K
S
L
H
D
K
K
S
Q
D
F
G
N
L
F
Dog
Lupus familis
XP_534241
2041
231068
S1858
K
S
S
H
D
K
K
S
Q
D
F
G
N
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1428
K
S
S
N
D
K
K
S
Q
D
F
G
N
L
F
Rat
Rattus norvegicus
P41516
1526
173202
P1351
F
F
P
L
D
D
T
P
P
K
T
K
M
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
N1741
K
S
S
H
D
K
K
N
Q
E
F
G
N
L
F
Chicken
Gallus gallus
O42131
1627
183228
N1447
K
M
S
Q
E
K
K
N
Q
D
F
G
N
I
F
Frog
Xenopus laevis
NP_001082502
1579
178601
P1403
T
E
S
P
E
N
A
P
P
K
N
K
A
V
P
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
T1433
K
T
T
F
T
L
P
T
S
T
A
K
K
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
P1272
E
P
K
V
K
K
E
P
K
G
K
Q
I
K
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
E1345
F
N
S
D
M
S
E
E
S
D
V
E
F
D
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
R1273
T
G
D
G
K
R
G
R
K
P
K
D
L
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
D1298
A
A
K
E
V
E
E
D
E
M
L
D
L
A
Q
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V1253
K
K
E
K
T
P
S
V
S
E
T
K
T
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
80
60
0
6.6
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
93.3
80
13.3
20
N.A.
26.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
7
0
0
0
7
0
7
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
47
7
0
7
0
47
0
14
0
14
0
% D
% Glu:
7
7
7
7
14
7
20
7
7
14
0
7
0
7
14
% E
% Phe:
14
7
0
7
0
0
0
0
0
0
47
0
7
0
47
% F
% Gly:
0
7
0
7
0
0
7
0
0
7
0
47
0
0
0
% G
% His:
0
0
0
34
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
7
% I
% Lys:
60
7
14
7
14
54
47
0
14
14
14
27
7
14
0
% K
% Leu:
0
0
20
7
0
7
0
0
0
0
7
0
14
40
0
% L
% Met:
0
7
0
0
7
0
0
0
0
7
0
0
7
0
0
% M
% Asn:
0
7
0
7
0
7
0
14
0
0
7
0
47
0
7
% N
% Pro:
0
7
7
7
0
7
7
20
14
7
0
0
0
7
14
% P
% Gln:
0
0
0
7
0
0
0
0
47
0
0
7
0
0
7
% Q
% Arg:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
40
40
0
0
7
7
34
20
0
0
0
0
0
0
% S
% Thr:
14
7
7
0
14
0
7
7
0
7
14
0
7
0
0
% T
% Val:
0
0
0
7
7
0
0
7
0
0
7
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _